PIAS Proteins Modulate Transcription Factors by Functioning as SUMO-1 Ligases
نویسندگان
چکیده
منابع مشابه
PIAS proteins promote SUMO-1 conjugation to STAT1.
Signal transducer and activator of transcription 1 (STAT1) is a critical mediator of interferon-gamma (IFN-gamma)-induced transcription that is regulated through posttranslational modifications and through transacting proteins such as protein inhibitor of activated STAT1 (PIAS1). PIAS proteins have been shown to function as E3-type small ubiquitin-like modifier (SUMO) ligases, and sumoylation h...
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The PIAS family of proteins was named based on the identification of the founding member, PIAS3, as a repressor of the activity of the STAT3 transcription factor (Protein Inhibitor of Activated STAT) (Chung et al. 1997). Since then, three additional family members— PIAS1, PIASy, and PIASx—have been identified and are characterized by a high degree of sequence conservation throughout the protein...
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In mammalian cells, DNA methylation is associated with heritable and stable gene repression, mediated in part by methyl-CpG-binding domain (MBD) proteins that recruit corepressors to modify chromatin. MBD1 protein, a member of the MBD family, forms a complex with SETDB1 histone methylase to silence transcription at target promoters by methylation of lysine 9 of histone H3. How MBD1-mediated tra...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2002
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.22.14.5222-5234.2002